Research Strategy and Studies

A summary of our research strategy for 2015-2017 can be viewed by clicking here.

The list below shows current studies in the Academic Directorate of Respiratory Medicine. For further information please contact jim.lithgow@sth.nhs.uk

Abbreviations:

  • CF – Cystic Fibrosis
  • COPD – Chronic Obstructive Pulmonary Disease
  • ILD – Interstitial Lung Disease
  • Inf / Imm - Inflammation & Immunity
  • PH – Pulmonary Hypertension
  • NIHR – National Institute for Health Research

Theme

Principal Investigator

Title

Funder

STH Number

Asthma

Sabroe

Screening of target genes for polymorphic variation which may alter treatment response for airway management

Clinical Research Network

18236

Asthma

Sabroe

Study of mechanisms of action of Omalizumab in severe asthma

Novartis

18753

Asthma

Sabroe

A 52-week, multi-center, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of QAW039 when added to existing asthma therapy in patients with uncontrolled severe asthma.

Novartis

19568

CF

Edenborough

Cystic Fibrosis Registry

Cystic Fibrosis Trust

14870

CF

Wildman

Quality of life measurement in people with cystic fibrosis registered with the UK CF Registry

Cystic Fibrosis Trust

19672

CF

Wildman

Development and evaluation of an intervention to support Adherence to treatment in adults with Cystic Fibrosis. A feasibility study comprised of an external pilot randomised controlled trial and process evaluation

NIHR

19213

CF

Wildman

ACtiF - Adherence to treatment in adults with Cystic Fibrosis 2.1C

NIHR

18989

CF

Wildman

Hyperpolarised gas MRI and multiple breath inert gas washout to improve management and understanding of cystic fibrosis lung disease.

NIHR Doctoral Fellowship (Sheffield Children's Hospital)

19553

COPD

Hughes

A Randomized, Double-Blind, Parallel Group, Multi-Centre Study to Assess the Efficacy and Safety of PT009 compared to PT005 on COPD Exacerbations over a 52-Week Treatment Period in Subjects With Moderate to Very Severe COPD

AstraZeneca

19703

COPD

Lawson

Lung magnetic resonance Imaging with FluorocarbonTracer gases

MRC/Newcastle University

19050

COPD

Lawson

A randomized, double-blind, placebo-controlled, two-period crossover study to assess the effect of inhaled QVA149 on global and regional lung function and gas exchange in patients with moderate to severe COPD

Novartis

19163

ILD

Bianchi

A 24-week, double-blind, randomized, parallel-group study evaluating the efficacy and safety of oral nintedanib co-administered with oral sildenafil, compared to treatment with nintedanib alone, in patients with idiopathic pulmonary fibrosis (IPF) and advanced lung function impairment

Boehringer Ingelheim Ltd

19516

ILD

Bianchi

Functional MRI and PETCT in Idiopathic Pulmonary Fibrosis

NIHR /

19345

ILD

Bianchi

The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary Fibrosis with the addition of Co-trimoxazole (EME-TIPAC)

NIHR / University of East Anglia

18188

ILD

Bianchi

Investigation into prognostic indicators of Idiopathic Pulmonary Fibrosis using structural-functional pulmonary MRI assessment

University of Sheffield (POLARIS)

18876

ILD

Renshaw

Identification of disease susceptibility genes and autoantibodies associated with the development and clinical characteristics of interstitial lung disease (ILD) in patients with and without proven connective tissue diseases (CTDs).

University of Liverpool

18616

Inf / Imm

Sabroe

The control of innate immunity, host pathogen interactions, and leukocyte function in healthy volunteers

Medical Research Council

13927

Mesothelioma

Lewis

Randomised controlled trial to compare the diagnostic yield of Positron Emission Tomography Computed Tomography TARGETed pleural biopsy versus CT guided pleural biopsy in suspected pleural malignancy

North Bristol NHS Trust / NIHR

19648

PH

Condliffe

Long term, multicenter, single-arm, open-label extension study of the MERIT-1 study, to assess the safety, tolerability and efficacy of macitentan in subjects with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) merit

Actelion Pharmaceuticals

18686

PH

Kiely

A randomized, double-blind, placebo-controlled, prospective, multicenter, parallel group study to assess the safety and efficacy of macitentan in patients with portopulmonary hypertension

Actelion Pharmaceuticals

18756

PH

Kiely

A prospective, multicenter, single-arm, open-label, Phase 4 study to evaluate the effects of macitentan on Right vEntricular remodeling in Pulmonary ArterIal hypeRtension assessed by cardiac magnetic resonance imaging - REPAIR

Actelion Pharmaceuticals

18766

PH

Kiely

What is the effect of intravenous iron supplementation on exercise capacity and quality of life in patients with IPAH and iron deficiency?

British Heart Foundation

16055

PH

Kiely

Investigation into osteoprotegrin (OPG) and related biomarkers in incident cases of pulmonary hypertension.

British Heart Foundation

16436

PH

Kiely

Investigation into predictors of diagnosis in PAH patients

IMS-Quintiles

18905

PH

Kiely

National Cohort Study of Idiopathic and Heritable Pulmonary Arterial Hypertension

Medical Research Council

17049

PH

Kiely

TRANSFORM-UK: A Therapeutic Open Label Study of Tocilizumab in the Treatment of Pulmonary Arterial Hypertension

NIHR/Papworth

19081

PH

Kiely

Assessing the Spectrum of Pulmonary Hypertension In a Referral Centre (ASPIRE Research Database)

Sheffield Pulmonary Vascular Disease Unit

14169

PH

Kiely

Pilot study: Use of Functional MRI to understand the pathophysiology of abnormalities of gas exchange in patients with idiopathic pulmonary fibrosis and systemic sclerosis

University of Sheffield (POLARIS)

16380

PH

Lawrie

PH BIOBANK - Investigation into osteoprotegrin and related biomarkers in incident cases of pulmonary hypertension.

British Heart Foundation

16436

PH

Swift

Reproducibility of Magnetic resonance imaging cardiopulmonary metrics in healthy volunteers and patients with pulmonary arterial hypertension – Implications for trial design

GSK

18285

Respiratory

Fishwick

Respiratory Medicine Research Database

STH Directorate Respiratory Research Fund

16261

Tissue Bank

Peachell

Sheffield Lung Research Tissue Bank

University of Sheffield

15662

For further information please contact jim.lithgow@sth.nhs.uk